Monoclonal Mouse Antibody to
Bcl-10 
F, P/H

Catalog No.: Mob 442 Concentrated 1ml
Mob 442-05 Concentrated 0.5ml

Immunogen: Human recombinant bcl-10
Clone: 151
Isotype: IgG1
Positive Control: Tonsil
Cellular Localization: Nuclear
Specificity: Monoclonal anti-bcl-10 reacts specifically with human bcl-10. The epitope recognized by the antibody resides within amino acids 122-168 of human bcl-10 molecule. Bcl-10, also designated as CIPER, mE10, cE10, CARMEN, and CLAP, is an N-terminal CARD (caspase recruitment domain) containing protein. It is a cellular homologue of the equine herpesvirus-2 protein E-10 (vCLAP). Bcl-10 was implicated in the regulation of apoptosis by interacting with caspase 9, enhancing procaspase 9 processing, and triggering its activation when overexpressed in the cell. Bcl-10 cellular overexpression induces JNK, p38, and NF-kB activation. Deregulation of bcl-10 expression was also demonstrated to be involved in cellular oncogenesis.

F=Frozen P=Formalin Fixed Paraffin Embedded H=Heat Induced Pretreatment E=Enzyme Pretreatment

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Additional Information