Monoclonal Mouse Antibody to
MLH-1 
F, P/H

Catalog No.: Mob 430 Concentrated 1ml
Mob 430-05 Concentrated 0.5ml
PDM 148 Prediluted 6ml

Immunogen: Full length recombinant MLH.
Clone: G168-15
Isotype: IgG1
Positive Control: Tonsil, colon carcinoma
Cellular Localization: Nuclear
Specificity: The G168-15 antibody recognizes human and mouse MLH1 (80-85kDa). The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. The importance of mismatch repair genes became apparent with the identification of the genetic basis for hereditary nonpolyposis colon cancer (HNPC). MSH-2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process. It is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a heterodimer of MLH1 and PMSH, which together help facilitate the later steps in mismatch
repair. This antibody cross-reacts with human, hamster and rat.

F=Frozen P=Formalin Fixed Paraffin Embedded H=Heat Induced Pretreatment E=Enzyme Pretreatment

For more information please visit the DBS website at dbiosys.com

Additional Information