Monoclonal Mouse Antibody to
MSH6 
F, P/H

Catalog No.: Mob 429 Concentrated 1ml
Mob 429-05 Concentrated 0.5ml
PDM 147 Prediluted 6ml

Immunogen: Human MSH6.
Clone: 44
Isotype: IgG1
Positive Control: Tonsil, colon carcinoma
Cellular Localization: Nuclear
Specificity: MSH6 is a heterodimer of MSH2 and binds to DNA containing G/T mismatches. The MSH2-MSH6 complex recognizes a single-base mispair insertion/deletion loop. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. Studies have shown the mutations of MLH-1, MSH2 and MSH6 genes contribute to the development of sporadic colorectal carcinoma.
The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. This antibody cross-reacts with mouse, rat and dog.

F=Frozen P=Formalin Fixed Paraffin Embedded H=Heat Induced Pretreatment E=Enzyme Pretreatment

For more information please visit the DBS website at dbiosys.com

Additional Information