Monoclonal Mouse Antibody to
p130/Rb2 
F, P/H

Catalog No.: Mob 368 Concentrated 1ml
Mob 368-05 Concentrated 0.5ml

Immunogen: BALB/C mice were injected with a synthetic peptide from p130 corresponding to amino acid 878–913.
Clone: 130p215
Isotype: IgG1
Positive Control: Tonsil
Cellular Localization: Nuclear
Specificity: This antibody reacts with a 130 kDa protein. Two retinoblastoma–related proteins, p107 and pRb2/p130 are structurally and functionally similar to the product of the retinoblastoma gene (pRb/p105). Both proteins play a fundamental role in growth control. The highest percentage of undetectable levels and the tightest inverse correlation with the histological grading and with PCNA expression in the most aggressive tumor types were found for pRb2/p130, which may suggest an important role for this protein in the pathogenesis and progression of lung cancer. This antibody cross-reacts with rat.

F=Frozen P=Formalin Fixed Paraffin Embedded H=Heat Induced Pretreatment E=Enzyme Pretreatment

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Additional Information