Monoclonal Mouse Antibody to
Mucin 5AC/Gastric Mucin 
F, P

Catalog No.: Mob 357 Concentrated 1ml
Mob 357-05 Concentrated 0.5ml

Immunogen: BALB/C mice were injected with M1 mucin preparation from the fluid of an ovarian mucinous cyst belonging to an O Le (a-b) patient.
Clone: 45M1
Isotype: IgG1, kappa
Positive Control: Stomach
Cellular Localization: Cytoplasmic, cell surface
Specificity: This antibody reacts with a 1000 kDa protein and recognizes the peptide core of gastric mucin M1. Mucins are high molecular weight glycoproteins with 80% carbohydrates and 20% core protein. Gastric mucin M1 antigen is found in columnar mucus cells of surface gastric epithelium and in goblet cells of the fetal and precancerous colon but not in normal colon. Resurgence of gastric mucin during colonic carcinogenesis is suggestive of either re-expression of the peptide core of gastric mucin in the adult colon or changes in the glycosylation pattern of mucin, which expose the hidden M1 antigen. It cross-reacts with monkey, rabbit, cat, mouse, rat, pig, hedgehog, and chicken.

F=Frozen P=Formalin Fixed Paraffin Embedded H=Heat Induced Pretreatment E=Enzyme Pretreatment

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Additional Information